Idiopathic Thrombocytopenic Purpura

There are noticeable red, rash-looking spots all over 5-year old Stacey’s torso. “Must be from all the rolling and tumbling on the grass that she did yesterday, ” Stacey’s mother justified. Days passed by, and these rashes did not go away, and Stacey was feeling weak and inactive most of the days. Large bruises appeared on her legs, which alarmed her mother greatly. “Not one family member of ours has this illness, and I am very meticulous in caring for Stacey, ” her mother told the pediatrician.  After thorough blood tests and physical exams, Stacey was diagnosed with idiopathic thrombocytopenic purpura.


Idiopathic Thrombocytopenia Purpura (ITP) has two distinct clinical syndromes, manifesting as an acute condition in children and a chronic condition in adults.

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ITP is a blood disorder characterized by an abnormal decrease in the number of platelets in the blood.
  • Idiopathic thrombocytopenic purpura (ITP), also known as primary immune thrombocytopenic purpura and autoimmune thrombocytopenic purpura, is defined as isolated thrombocytopenia with normal bone marrow and in the absence of other causes of thrombocytopenia.
  • ITP is a disorder that can lead to easy or excessive bruising and bleeding.
  • Children often develop ITP after a viral infection and usually recover fully without treatment.


The bleeding results from unusually low levels of platelets — the cells that help blood clot.

  • ITP is primarily a disease of increased peripheral platelet destruction, with most patients having antibodies to specific platelet membrane glycoproteins.
  • Relative marrow failure may contribute to this condition since studies show that most patients have either normal or diminished platelet production.
  • Acute ITP often follows an acute infection and has a spontaneous resolution within 2 months.
  • Chronic ITP persists longer than 6 months without a specific cause.

Statistics and Incidences

Incidence rates of idiopathic thrombocytopenic purpura (ITP) are as follows:

  • An average estimate of the incidence in children is 50 cases per 1,000,000 per year.
  • New cases of chronic refractory ITP comprise approximately 10 cases per 1,000,000 per year
  • According to studies in Denmark and England, childhood ITP occurs in approximately 10-40 cases per 1,000,000 per year.
  • A prospective, population-based study in Norway indicated an incidence of 53 per 1,000,000 in children younger than 15 years.
  • A study in Kuwait reported a higher incidence of 125 cases per 1,000,000 per year.
  • The mortality rate from hemorrhage is approximately 1% in children and 5% in adults.
  • Spontaneous remission occurs in more than 80% of cases in children.
  • Peak prevalence occurs in children aged 2-4 years.
  • Approximately 40% of all patients are younger than 10 years.
  • In acute ITP (children), distribution is equal between males (52%) and females (48%).


If the cause of this immune reaction is unknown, the condition is called idiopathic thrombocytopenic purpura. Idiopathic means “of unknown cause.”

  • Increased breakdown of platelets. In people with ITP, antibodies produced by the immune system attach themselves to the platelets, marking the platelets for destruction; the spleen, which helps the body fight infection, recognizes the antibodies and removes the platelets from the system; the result of this case of mistaken identity is a lower number of circulating platelets than is normal.

Clinical Manifestations

Clinical features of idiopathic thrombocytopenic purpura (ITP):

ITP can result in easy bruising, bleeding gums and internal bleeding. | Health Life Media
  • Petechiae. Petechiae appear when capillaries bleed, leaking blood into the skin.
  • Purpura. Easy or excessive bruising or purpura is dominant; if bone marrow megakaryocytes cannot increase production and maintain a normal number of circulating platelets, thrombocytopenia and purpura develop.
  • Hemorrhage. Hemorrhagic bullae on mucous membranes, gingival bleeding, signs of GI bleeding, retinal hemorrhages, and evidence of intracranial hemorrhage, with possible neurologic symptoms; the bleeding results from unusually low levels of platelets — the cells that help blood clot.
  • Nonpalpable spleen. The prevalence of palpable spleen in patients with ITP is approximately the same as that in the non-ITP population (ie, 3% in adults, 12% in children); despite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged.
  • Spontaneous bleeding. Spontaneous bleeding occur when platelet count is less than 20,000/mm3.

Assessment and Diagnostic Findings

Diagnosis of idiopathic thrombocytopenic purpura includes:

  • Laboratory studies. Isolated thrombocytopenia on a complete blood cell count (CBC) is the key laboratory finding; the white blood cell (WBC) count and hemoglobin level typically are normal, unless severe hemorrhage has occurred; on peripheral smear, truly giant platelets suggest congenital thrombocytopenia.
  • Imaging studies. A CT scan of the head is warranted if concern exists regarding intracranial hemorrhage.

Medical Management

Treatment may include a number of approaches, such as medications to boost platelet count or surgery to remove spleen (splenectomy).

  • Prehospital care. Prehospital care focuses on the ABCs (airway, breathing, circulation), which include providing oxygen, controlling severe hemorrhage, and initiating intravenous (IV) fluids to maintain hemodynamic stability; airway control may be necessary for a large intracranial hemorrhage.
  • Emergency department care. Life-threatening bleeding requires conventional critical care interventions; in the patient with known ITP, high-dose parenteral glucocorticoids and IV immunoglobulin (IVIg), with or without platelet transfusions, are appropriate.
  • Consultations. Consult a hematologist for assistance in confirming the diagnosis or, in the patient with known ITP, arranging disposition and follow-up care, if appropriate.

Pharmacologic Management

Glucocorticoids and intravenous immunoglobulin (IVIg) are the mainstays of medical therapy for idiopathic thrombocytopenic purpura (ITP).

  • Glucocorticoids. These agents are used to treat idiopathic and acquired autoimmune disorders; they have been shown to increase platelet count in ITP.
  • Blood products. Administration of IVIg may temporarily increase platelet counts in some children and adults with ITP; consider IVIg if the situation requires a rapid, temporary rise in platelet count.
  • Thrombopoeitic. These agents directly stimulate bone marrow platelet production.

Nursing Management

Nursing care for a child with idiopathic thrombocytopenia purpura include:

Nursing Assessment

Assessment in a child with ITP include the following:

  • History. Medications can be a common etiology for inducing thrombocytopenia, and patients should have their medications carefully reviewed; one study used three distinct methods to document drugs that may be associated with drug-induced immune thrombocytopenia (DITP).
  • Physical exam. Address risk factors for increased bleeding, such as GI disease, CNS disease, urologic disease, or active lifestyle, as these may determine the aggressiveness of management.

Nursing Diagnoses

Based on the assessment data, the major nursing diagnoses for idiopathic thrombocytopenis purpura are:

Nursing Care Planning and Goals

The major nursing care planning goals for idiopathic thrombocytopenic purpura are:

  • Patient or caregivers take measures to prevent bleeding and recognize signs of bleeding that need to be reported immediately to a health care professional.
  • Patient does not experience bleeding as evidenced by normal blood pressure, stable hematocrit and hemoglobin levels and desired ranges for coagulation profiles.
  • Patient remains free of injuries.
  • Patient increases daily activity, if feasible.
  • Patient remains free of infection, as evidenced by normal vital signs and absence of signs and symptoms of infection.
  • Early recognition of infection to allow for prompt treatment.

Nursing Interventions

Nursing interventions for a child with ITP are:

  • Prevent bleeding. Review laboratory results for coagulation status as appropriate: platelet count, prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), fibrinogen, bleeding time, fibrin degradation products, vitamin K, activated coagulation time (ACT); and educate the at-risk patient and caregivers about precautionary measures to prevent tissue trauma or disruption of the normal clotting mechanisms.
  • Prevent injury. Thoroughly conform patient to surroundings; put call light within reach and teach how to call for assistance; respond to call light immediately; avoid use of restraints; obtain a physician’s order if restraints are needed; and eliminate or drop all possible hazards in the room such as razors, medications, and matches.
  • Prevent infection. Wash hands and teach patient and SO to wash hands before contact with patients and between procedures with the patient; encourage fluid intake of 2,000 to 3,000 mL of water per day, unless contraindicated; recommend the use of soft-bristled toothbrushes and stool softeners to protect mucous membranes; and if infection occurs, teach the patient to take antibiotics as prescribed; instruct patient to take the full course of antibiotics even if symptoms improve or disappear.


Goals are met as evidenced by:

  • Patient or caregivers took measures to prevent bleeding and recognized signs of bleeding that need to be reported immediately to a health care professional.
  • Patient did not experience bleeding as evidenced by normal blood pressure, stable hematocrit and hemoglobin levels and desired ranges for coagulation profiles.
  • Patient remained free of injuries.
  • Patient increased daily activity, if feasible.
  • Patient remained free of infection, as evidenced by normal vital signs and absence of signs and symptoms of infection.
  • Early recognition of infection allowed for prompt treatment.

Documentation Guidelines

Documentation in a child with ITP include the following:

  • Baseline and subsequent assessment findings to include signs and symptoms.
  • Individual cultural or religious restrictions and personal preferences.
  • Plan of care and persons involved.
  • Teaching plan.
  • Client’s responses to teachings, interventions, and actions performed.
  • Attainment or progress toward the desired outcome.
  • Long-term needs, and who is responsible for actions to be taken.

Practice Quiz: Idiopathic Thrombocytopenic Purpura

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Practice Quiz: Idiopathic Thrombocytopenic Purpura

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1. Which of the following drugs would be ordered by the physician to improve the platelet count in a male client with idiopathic thrombocytopenic purpura (ITP)?

A. Acetylsalicylic acid (ASA)
B. Corticosteroids
C. Methotrexate
D. Vitamin K

1. Answer: B. Corticosteroids.

  • Option B: Corticosteroid therapy can decrease antibody production and phagocytosis of the antibody-coated platelets, retaining more functioning platelets.
  • Option C: Methotrexate can cause thrombocytopenia.
  • Options A and D: Vitamin K is used to treat an excessive anticoagulate state from warfarin overload, and ASA decreases platelet aggregation.

2. Nurse Hannah is administering a steroid to a child diagnosed with idiopathic thrombocytopenic purpura (ITP); which of the following should the nurse monitor?

A. Infection
B. Anemia
C. Bleeding
D. Bruising

2. Answer: A. Infection.

  • Option A: Steroids may promote immunosuppression, making the child more susceptible to infections.
  • Option B: Anemia is not connected to the disorder or medication.
  • Options C and D: Bleeding and bruising are recognized as a result of the disorder, not the steroid therapy.

3. Mr. and Mrs. Robertson’s son was diagnosed with idiopathic thrombocytopenic purpura. They should be aware that the drug to be avoided is:

A. Acetaminophen
B. Aspirin
C. Codeine
D. Morphine

3. Answer: B. Aspirin.

  • Option B: Aspirin exerts an antiplatelet action and therefore may increase platelet destruction in ITP.
  • Options A, C, and D: Acetaminophen, codeine, and morphine have no effect on platelets and, therefore, are not contraindicated.

4. Corticosteroids are potent suppressors of the body’s inflammatory response. Which of the following conditions or actions do they suppress?

A. Cushing syndrome
B. Pain receptors
C. Immune response
D. Neural transmission

4. Answer: C. Immune response.

  • Option C: Corticosteroids suppress eosinophils, lymphocytes, and natural killer cells, inhibiting the natural inflammatory process in an infected or injured part of the body.
  • Option A: Excessive corticosteroid therapy can lead to Cushing’s syndrome.
  • Options B and D: Corticosteroids do not suppress the pain receptors and neural transmission.

5. A client is receiving a platelet transfusion. The nurse determines that the client is gaining from this therapy if the client exhibits which of the following?

A. Less frequent febrile episodes
B. Increased level of hematocrit
C. Less episodes of bleeding
D. Increased level of hemoglobin

5. Answer: C. Less episodes of bleeding.

  • Options C: Platelet transfusions may be given to prevent bleeding when the platelet count falls down.
  • Options A: A decline in the febrile episode will happen after the transfusion of agranulocytes.
  • Options B and D: An increased level of hemoglobin and hematocrit will happen after the transfusion of red blood cells.

See Also

Related topics to this study guide:

Further Reading

Recommended resources and books for pediatric nursing:

  1. PedsNotes: Nurse’s Clinical Pocket Guide (Nurse’s Clinical Pocket Guides)
  2. Pediatric Nursing Made Incredibly Easy
  3. Wong’s Essentials of Pediatric Nursing
  4. Pediatric Nursing: The Critical Components of Nursing Care

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